Single-neuron representation of learned complex sounds in the auditory cortex

Meng Wang, Xiang Liao (), Ruijie Li, Shanshan Liang, Ran Ding, Jingcheng Li, Jianxiong Zhang, Wenjing He, Ke Liu, Junxia Pan, Zhikai Zhao, Tong Li, Kuan Zhang, Xingyi Li, Jing Lyu, Zhenqiao Zhou, Zsuzsanna Varga, Yuanyuan Mi, Yi Zhou, Junan Yan, Shaoqun Zeng, Jian K. Liu, Arthur Konnerth, Israel Nelken, Hongbo Jia () and Xiaowei Chen ()
Additional contact information
Meng Wang: Third Military Medical University
Xiang Liao: Chongqing University
Ruijie Li: Third Military Medical University
Shanshan Liang: Third Military Medical University
Ran Ding: Third Military Medical University
Jingcheng Li: Third Military Medical University
Jianxiong Zhang: Third Military Medical University
Wenjing He: Third Military Medical University
Ke Liu: Third Military Medical University
Junxia Pan: Third Military Medical University
Zhikai Zhao: Third Military Medical University
Tong Li: Third Military Medical University
Kuan Zhang: Third Military Medical University
Xingyi Li: Third Military Medical University
Jing Lyu: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Zhenqiao Zhou: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Zsuzsanna Varga: Technical University Munich
Yuanyuan Mi: Chongqing University
Yi Zhou: Guangxi University
Junan Yan: Guangxi University
Shaoqun Zeng: Huazhong University of Science and Technology
Jian K. Liu: University of Leicester
Arthur Konnerth: Technical University Munich
Israel Nelken: Hebrew University
Hongbo Jia: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Xiaowei Chen: Third Military Medical University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract The sensory responses of cortical neuronal populations following training have been extensively studied. However, the spike firing properties of individual cortical neurons following training remain unknown. Here, we have combined two-photon Ca2+ imaging and single-cell electrophysiology in awake behaving mice following auditory associative training. We find a sparse set (~5%) of layer 2/3 neurons in the primary auditory cortex, each of which reliably exhibits high-rate prolonged burst firing responses to the trained sound. Such bursts are largely absent in the auditory cortex of untrained mice. Strikingly, in mice trained with different multitone chords, we discover distinct subsets of neurons that exhibit bursting responses specifically to a chord but neither to any constituent tone nor to the other chord. Thus, our results demonstrate an integrated representation of learned complex sounds in a small subset of cortical neurons.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18142-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18142-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18142-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().