Integration of molecular profiles in a longitudinal wellness profiling cohort

Abdellah Tebani, Anders Gummesson, Wen Zhong, Ina Schuppe Koistinen, Tadepally Lakshmikanth, Lisa M. Olsson, Fredrik Boulund, Maja Neiman, Hans Stenlund, Cecilia Hellström, Max J. Karlsson, Muhammad Arif, Tea Dodig-Crnković, Adil Mardinoglu, Sunjae Lee, Cheng Zhang, Yang Chen, Axel Olin, Jaromir Mikes, Hanna Danielsson, Kalle Feilitzen, Per-Anders Jansson, Oskar Angerås, Mikael Huss, Sanela Kjellqvist, Jacob Odeberg, Fredrik Edfors, Valentina Tremaroli, Björn Forsström, Jochen M. Schwenk, Peter Nilsson, Thomas Moritz, Fredrik Bäckhed, Lars Engstrand, Petter Brodin, Göran Bergström, Mathias Uhlen and Linn Fagerberg ()
Additional contact information
Abdellah Tebani: KTH Royal Institute of Technology
Anders Gummesson: University of Gothenburg
Wen Zhong: KTH Royal Institute of Technology
Ina Schuppe Koistinen: KTH Royal Institute of Technology
Tadepally Lakshmikanth: Karolinska Institutet
Lisa M. Olsson: University of Gothenburg
Fredrik Boulund: Karolinska Institutet
Maja Neiman: KTH Royal Institute of Technology
Hans Stenlund: Umeå University
Cecilia Hellström: KTH Royal Institute of Technology
Max J. Karlsson: KTH Royal Institute of Technology
Muhammad Arif: KTH Royal Institute of Technology
Tea Dodig-Crnković: KTH Royal Institute of Technology
Adil Mardinoglu: KTH Royal Institute of Technology
Sunjae Lee: KTH Royal Institute of Technology
Cheng Zhang: KTH Royal Institute of Technology
Yang Chen: Karolinska Institutet
Axel Olin: Karolinska Institutet
Jaromir Mikes: Karolinska Institutet
Hanna Danielsson: Karolinska Institutet
Kalle Feilitzen: KTH Royal Institute of Technology
Per-Anders Jansson: University of Gothenburg
Oskar Angerås: University of Gothenburg
Mikael Huss: Codon Consulting
Sanela Kjellqvist: Karolinska Institutet
Jacob Odeberg: KTH Royal Institute of Technology
Fredrik Edfors: KTH Royal Institute of Technology
Valentina Tremaroli: University of Gothenburg
Björn Forsström: KTH Royal Institute of Technology
Jochen M. Schwenk: KTH Royal Institute of Technology
Peter Nilsson: KTH Royal Institute of Technology
Thomas Moritz: Swedish University of Agricultural Sciences
Fredrik Bäckhed: University of Gothenburg
Lars Engstrand: Karolinska Institutet
Petter Brodin: Karolinska Institutet
Göran Bergström: University of Gothenburg
Mathias Uhlen: KTH Royal Institute of Technology
Linn Fagerberg: KTH Royal Institute of Technology

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

Date: 2020
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DOI: 10.1038/s41467-020-18148-7

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