Generation, localization and functions of macrophages during the development of testis

Emmi Lokka, Laura Lintukorpi, Sheyla Cisneros-Montalvo, Juho-Antti Mäkelä, Sofia Tyystjärvi, Venla Ojasalo, Heidi Gerke, Jorma Toppari, Pia Rantakari () and Marko Salmi ()
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Emmi Lokka: University of Turku
Laura Lintukorpi: University of Turku
Sheyla Cisneros-Montalvo: University of Turku
Juho-Antti Mäkelä: University of Turku
Sofia Tyystjärvi: University of Turku
Venla Ojasalo: University of Turku
Heidi Gerke: University of Turku
Jorma Toppari: University of Turku
Pia Rantakari: University of Turku
Marko Salmi: University of Turku

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract In the testis, interstitial macrophages are thought to be derived from the yolk sac during fetal development, and later replaced by bone marrow-derived macrophages. By contrast, the peritubular macrophages have been reported to emerge first in the postnatal testis and solely represent descendants of bone marrow-derived monocytes. Here, we define new monocyte and macrophage types in the fetal and postnatal testis using high-dimensional single-cell analyses. Our results show that interstitial macrophages have a dominant contribution from fetal liver-derived precursors, while peritubular macrophages are generated already at birth from embryonic precursors. We find that bone marrow-derived monocytes do not substantially contribute to the replenishment of the testicular macrophage pool even after systemic macrophage depletion. The presence of macrophages prenatally, but not postnatally, is necessary for normal spermatogenesis. Our multifaceted data thus challenge the current paradigms in testicular macrophage biology by delineating their differentiation, homeostasis and functions.

Date: 2020
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DOI: 10.1038/s41467-020-18206-0

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