Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

Rui Wang, Miusi Shi, Feiyan Xu, Yun Qiu, Peng Zhang, Kailun Shen, Qin Zhao, Jiaguo Yu () and Yufeng Zhang ()
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Rui Wang: Wuhan University
Miusi Shi: Wuhan University
Feiyan Xu: Xianhu Hydrogen Valley
Yun Qiu: Wuhan University
Peng Zhang: Wuhan University
Kailun Shen: Wuhan University
Qin Zhao: Wuhan University
Jiaguo Yu: Xianhu Hydrogen Valley
Yufeng Zhang: Wuhan University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.

Date: 2020
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DOI: 10.1038/s41467-020-18267-1

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