Caspase-8 mediates inflammation and disease in rodent malaria

Larissa M. N. Pereira, Patrícia A. Assis, Natalia M. Araújo, Danielle F. Durso, Caroline Junqueira, Marco Antônio Ataíde, Dhelio B. Pereira, Egil Lien, Katherine A. Fitzgerald, Dario S. Zamboni, Douglas T. Golenbock and Ricardo T. Gazzinelli ()
Additional contact information
Larissa M. N. Pereira: Instituto Rene Rachou, FIOCRUZ-MG
Patrícia A. Assis: University of Massachusetts Medical School
Natalia M. Araújo: Instituto Rene Rachou, FIOCRUZ-MG
Danielle F. Durso: University of Massachusetts Medical School
Caroline Junqueira: Instituto Rene Rachou, FIOCRUZ-MG
Marco Antônio Ataíde: Instituto Rene Rachou, FIOCRUZ-MG
Dhelio B. Pereira: Centro de Pesquisas em Medicina Tropical, FIOCRUZ-RO
Egil Lien: University of Massachusetts Medical School
Katherine A. Fitzgerald: University of Massachusetts Medical School
Dario S. Zamboni: Universidade de São Paulo
Douglas T. Golenbock: Instituto Rene Rachou, FIOCRUZ-MG
Ricardo T. Gazzinelli: Instituto Rene Rachou, FIOCRUZ-MG

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM). Importantly, our results indicate that the combined deficiencies of caspases-8/1/11 or caspase-8/gasdermin-D (GSDM-D) renders mice impaired to produce both TNFα and IL-1β and highly resistant to lethality in these models, disclosing a complementary, but independent role of caspase-8 and caspases-1/11/GSDM-D in the pathogenesis of malaria. Further, we find that monocytes from malaria patients express active caspases-1, -4 and -8 suggesting that these inflammatory caspases may also play a role in the pathogenesis of human disease.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18295-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18295-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18295-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().