Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Leonidas S. Lundell, Evelyn B. Parr, Brooke L. Devlin, Lars R. Ingerslev, Ali Altıntaş, Shogo Sato, Paolo Sassone-Corsi, Romain Barrès, Juleen R. Zierath () and John A. Hawley ()
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Leonidas S. Lundell: University of Copenhagen
Evelyn B. Parr: Australian Catholic University
Brooke L. Devlin: Australian Catholic University
Lars R. Ingerslev: University of Copenhagen
Ali Altıntaş: University of Copenhagen
Shogo Sato: University of California, Irvine
Paolo Sassone-Corsi: University of California, Irvine
Romain Barrès: University of Copenhagen
Juleen R. Zierath: University of Copenhagen
John A. Hawley: Australian Catholic University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.

Date: 2020
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DOI: 10.1038/s41467-020-18412-w

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