Hippocampal hub neurons maintain distinct connectivity throughout their lifetime

Marco Bocchio (), Claire Gouny, David Angulo-Garcia, Tom Toulat, Thomas Tressard, Eleonora Quiroli, Agnès Baude and Rosa Cossart ()
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Marco Bocchio: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
Claire Gouny: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
David Angulo-Garcia: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
Tom Toulat: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
Thomas Tressard: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
Eleonora Quiroli: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
Agnès Baude: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy
Rosa Cossart: INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems (CENTURI), Parc Scientifique de Luminy

Nature Communications, 2020, vol. 11, issue 1, 1-19

Abstract: Abstract The temporal embryonic origins of cortical GABA neurons are critical for their specialization. In the neonatal hippocampus, GABA cells born the earliest (ebGABAs) operate as ‘hubs’ by orchestrating population synchrony. However, their adult fate remains largely unknown. To fill this gap, we have examined CA1 ebGABAs using a combination of electrophysiology, neurochemical analysis, optogenetic connectivity mapping as well as ex vivo and in vivo calcium imaging. We show that CA1 ebGABAs not only operate as hubs during development, but also maintain distinct morpho-physiological and connectivity profiles, including a bias for long-range targets and local excitatory inputs. In vivo, ebGABAs are activated during locomotion, correlate with CA1 cell assemblies and display high functional connectivity. Hence, ebGABAs are specified from birth to ensure unique functions throughout their lifetime. In the adult brain, this may take the form of a long-range hub role through the coordination of cell assemblies across distant regions.

Date: 2020
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DOI: 10.1038/s41467-020-18432-6

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