Entamoeba and Giardia parasites implicated as hosts of CRESS viruses

Cormac M. Kinsella (), Aldert Bart, Martin Deijs, Patricia Broekhuizen, Joanna Kaczorowska, Maarten F. Jebbink, Tom Gool, Matthew Cotten and Lia Hoek ()
Additional contact information
Cormac M. Kinsella: Amsterdam UMC, University of Amsterdam
Aldert Bart: Amsterdam UMC, University of Amsterdam
Martin Deijs: Amsterdam UMC, University of Amsterdam
Patricia Broekhuizen: Amsterdam UMC, University of Amsterdam
Joanna Kaczorowska: Amsterdam UMC, University of Amsterdam
Maarten F. Jebbink: Amsterdam UMC, University of Amsterdam
Tom Gool: Amsterdam UMC, University of Amsterdam
Matthew Cotten: MRC/UVRI & LSHTM Uganda Research Unit
Lia Hoek: Amsterdam UMC, University of Amsterdam

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Metagenomic techniques have enabled genome sequencing of unknown viruses without isolation in cell culture, but information on the virus host is often lacking, preventing viral characterisation. High-throughput methods capable of identifying virus hosts based on genomic data alone would aid evaluation of their medical or biological relevance. Here, we address this by linking metagenomic discovery of three virus families in human stool samples with determination of probable hosts. Recombination between viruses provides evidence of a shared host, in which genetic exchange occurs. We utilise networks of viral recombination to delimit virus-host clusters, which are then anchored to specific hosts using (1) statistical association to a host organism in clinical samples, (2) endogenous viral elements in host genomes, and (3) evidence of host small RNA responses to these elements. This analysis suggests two CRESS virus families (Naryaviridae and Nenyaviridae) infect Entamoeba parasites, while a third (Vilyaviridae) infects Giardia duodenalis. The trio supplements five CRESS virus families already known to infect eukaryotes, extending the CRESS virus host range to protozoa. Phylogenetic analysis implies CRESS viruses infecting multicellular life have evolved independently on at least three occasions.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18474-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18474-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18474-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().