Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

Rong Zhang, Ning Dong, Zhangqi Shen, Yu Zeng, Jiauyue Lu, Congcong Liu, Hongwei Zhou, Yanyan Hu, Qiaoling Sun, Qipeng Cheng, Lingbing Shu, Jiachang Cai, Edward Wai-Chi Chan, Gongxiang Chen () and Sheng Chen ()
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Rong Zhang: Second Affiliated Hospital of Zhejiang University, School of Medicine
Ning Dong: City University of Hong Kong
Zhangqi Shen: China Agricultural University
Yu Zeng: Second Affiliated Hospital of Zhejiang University, School of Medicine
Jiauyue Lu: Second Affiliated Hospital of Zhejiang University, School of Medicine
Congcong Liu: Second Affiliated Hospital of Zhejiang University, School of Medicine
Hongwei Zhou: Second Affiliated Hospital of Zhejiang University, School of Medicine
Yanyan Hu: Second Affiliated Hospital of Zhejiang University, School of Medicine
Qiaoling Sun: Second Affiliated Hospital of Zhejiang University, School of Medicine
Qipeng Cheng: City University of Hong Kong
Lingbing Shu: Second Affiliated Hospital of Zhejiang University, School of Medicine
Jiachang Cai: Second Affiliated Hospital of Zhejiang University, School of Medicine
Edward Wai-Chi Chan: The Hong Kong Polytechnic University
Gongxiang Chen: Second Affiliated Hospital of Zhejiang University, School of Medicine
Sheng Chen: City University of Hong Kong

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Emergence of tigecycline-resistance tet(X) gene orthologues rendered tigecycline ineffective as last-resort antibiotic. To understand the potential origin and transmission mechanisms of these genes, we survey the prevalence of tet(X) and its orthologues in 2997 clinical E. coli and K. pneumoniae isolates collected nationwide in China with results showing very low prevalence on these two types of strains, 0.32% and 0%, respectively. Further surveillance of tet(X) orthologues in 3692 different clinical Gram-negative bacterial strains collected during 1994–2019 in hospitals in Zhejiang province, China reveals 106 (2.7%) tet(X)-bearing strains with Flavobacteriaceae being the dominant (97/376, 25.8%) bacteria. In addition, tet(X)s are found to be predominantly located on the chromosomes of Flavobacteriaceae and share similar GC-content as Flavobacteriaceae. It also further evolves into different orthologues and transmits among different species. Data from this work suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance gene tet(X).

Date: 2020
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DOI: 10.1038/s41467-020-18475-9

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