Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Jan Krivanek, Ruslan A. Soldatov, Maria Eleni Kastriti, Tatiana Chontorotzea, Anna Nele Herdina, Julian Petersen, Bara Szarowska, Marie Landova, Veronika Kovar Matejova, Lydie Izakovicova Holla, Ulrike Kuchler, Ivana Vidovic Zdrilic, Anushree Vijaykumar, Anamaria Balic, Pauline Marangoni, Ophir D. Klein, Vitor C. M. Neves, Val Yianni, Paul T. Sharpe, Tibor Harkany, Brian D. Metscher, Marc Bajénoff, Mina Mina, Kaj Fried, Peter V. Kharchenko () and Igor Adameyko ()
Additional contact information
Jan Krivanek: Medical University of Vienna
Ruslan A. Soldatov: Harvard Medical School
Maria Eleni Kastriti: Medical University of Vienna
Tatiana Chontorotzea: Medical University of Vienna
Anna Nele Herdina: Karolinska Institutet
Julian Petersen: Medical University of Vienna
Bara Szarowska: Medical University of Vienna
Marie Landova: Institute of Animal Physiology and Genetics, CAS
Veronika Kovar Matejova: Masaryk University
Lydie Izakovicova Holla: Masaryk University
Ulrike Kuchler: Medical University of Vienna
Ivana Vidovic Zdrilic: University of Connecticut Health Center
Anushree Vijaykumar: University of Connecticut Health Center
Anamaria Balic: University of Helsinki
Pauline Marangoni: University of California
Ophir D. Klein: University of California
Vitor C. M. Neves: Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London
Val Yianni: Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London
Paul T. Sharpe: Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London
Tibor Harkany: Medical University of Vienna
Brian D. Metscher: University of Vienna
Marc Bajénoff: Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS UMR
Mina Mina: University of Connecticut Health Center
Kaj Fried: Karolinska Institutet
Peter V. Kharchenko: Harvard Medical School
Igor Adameyko: Medical University of Vienna

Nature Communications, 2020, vol. 11, issue 1, 1-18

Abstract: Abstract Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18512-7

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DOI: 10.1038/s41467-020-18512-7

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