Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Prasun Dutta, Andrea Talenti, Rachel Young, Siddharth Jayaraman, Rebecca Callaby, Santosh Kumar Jadhav, Velu Dhanikachalam, Mayakannan Manikandan, Bhim B. Biswa, Wai Y. Low, John L. Williams, Elizabeth Cook, Phil Toye, Eileen Wall, Appolinaire Djikeng, Karen Marshall, Alan L. Archibald, Suresh Gokhale, Satish Kumar, David A. Hume () and James G. D. Prendergast ()
Additional contact information
Prasun Dutta: University of Edinburgh
Andrea Talenti: University of Edinburgh
Rachel Young: University of Edinburgh
Siddharth Jayaraman: University of Edinburgh
Rebecca Callaby: University of Edinburgh
Santosh Kumar Jadhav: Central Research Station
Velu Dhanikachalam: Central Research Station
Mayakannan Manikandan: Centre for Cellular and Molecular Biology
Bhim B. Biswa: Centre for Cellular and Molecular Biology
Wai Y. Low: University of Adelaide
John L. Williams: University of Adelaide
Elizabeth Cook: International Livestock Research Institute (ILRI)
Phil Toye: International Livestock Research Institute (ILRI)
Eileen Wall: Scotland’s Rural College (SRUC)
Appolinaire Djikeng: Centre for Tropical Livestock Genetics and Health
Karen Marshall: International Livestock Research Institute (ILRI)
Alan L. Archibald: University of Edinburgh
Suresh Gokhale: Central Research Station
Satish Kumar: Centre for Cellular and Molecular Biology
David A. Hume: Translational Research Institute
James G. D. Prendergast: University of Edinburgh

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes representing 13 global breeds. The genomic regions under selection between cattle breeds significantly overlap regions linked to stature in human genetic studies, with a disproportionate number of these loci also shown to be under selection between water buffalo breeds. Investigation of potential functional variants in the water buffalo genome identifies a rare example of convergent domestication down to the same mutation having independently occurred and been selected for across domesticated species. Cross-species comparisons of recent selective sweeps can consequently help identify and refine important loci linked to domestication.

Date: 2020
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DOI: 10.1038/s41467-020-18550-1

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