Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions

Meng Liu, Azzurra Apriceno, Miguel Sipin, Edoardo Scarpa, Laura Rodriguez-Arco, Alessandro Poma, Gabriele Marchello, Giuseppe Battaglia () and Stefano Angioletti-Uberti ()
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Meng Liu: Beijing University of Chemical Technology
Azzurra Apriceno: University College London
Miguel Sipin: University College London
Edoardo Scarpa: University College London
Laura Rodriguez-Arco: University College London
Alessandro Poma: University College London
Gabriele Marchello: University College London
Giuseppe Battaglia: University College London
Stefano Angioletti-Uberti: Chinese Academy of Science

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract From viruses to nanoparticles, constructs functionalized with multiple ligands display peculiar binding properties that only arise from multivalent effects. Using statistical mechanical modelling, we describe here how multivalency can be exploited to achieve what we dub range selectivity, that is, binding only to targets bearing a number of receptors within a specified range. We use our model to characterise the region in parameter space where one can expect range selective targeting to occur, and provide experimental support for this phenomenon. Overall, range selectivity represents a potential path to increase the targeting selectivity of multivalent constructs.

Date: 2020
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DOI: 10.1038/s41467-020-18603-5

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