Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock

Sarina Harshuk-Shabso, Hila Dressler, Christof Niehrs, Emil Aamar and David Enshell-Seijffers ()
Additional contact information
Sarina Harshuk-Shabso: The Azrieli Faculty of Medicine, Bar-Ilan university
Hila Dressler: The Azrieli Faculty of Medicine, Bar-Ilan university
Christof Niehrs: Deutsches Krebsforschungszentrum (DKFZ)
Emil Aamar: The Azrieli Faculty of Medicine, Bar-Ilan university
David Enshell-Seijffers: The Azrieli Faculty of Medicine, Bar-Ilan university

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Tissue growth in the adult is an orchestrated process that often requires biological clocks to time stem cell and progenitor activity. Here, we employed the hair follicle, which cycles between growth and regression in a timely-restricted mode, to show that some components of the hair cycle clock reside within the mesenchymal niche of the hair follicle, the dermal papilla (DP), and both Fgf and Wnt signaling pathways interact within the DP to regulate the expression of these components that include Wnt agonists (Rspondins) and antagonists (Dkk2 and Notum). The levels of Wnt agonists and antagonists in the DP are progressively reduced and elevated during the growth phase, respectively. Consequently, Wnt signaling activity in the overlying epithelial progenitor cells decreases, resulting in the induction of the regression phase. Remarkably, DP properties allow Wnt activity in the DP to persist despite the Wnt-inhibiting milieu and consequently synchronize the induction and progression of the regression phase. This study provides insight into the importance of signaling crosstalk in coupling progenitors and their niche to regulate tissue growth.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18643-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18643-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18643-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().