Interleukin-8 as a candidate for thymoma identification and recurrence surveillance

Shilin Gao, Jiahao Jiang, Chun Jin, Jian Gao, Dian Xiong, Pengjie Yang, Shuzhong Cui, Wenhao Yang, Qibin Leng, Jihong Dong, Gang Chen, Junzhen Liu, Li Wang, Aiwu Ke, Haikun Wang () and Jianyong Ding ()
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Shilin Gao: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Jiahao Jiang: Zhongshan Hospital, Fudan University
Chun Jin: Zhongshan Hospital, Fudan University
Jian Gao: Zhongshan Hospital, Fudan University
Dian Xiong: Xuhui Central Hospital
Pengjie Yang: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Shuzhong Cui: Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Wenhao Yang: Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Qibin Leng: Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Jihong Dong: Zhongshan Hospital, Fudan University
Gang Chen: Zhongshan Hospital, Fudan University
Junzhen Liu: Zhongshan Hospital, Fudan University
Li Wang: Zhongshan Hospital, Fudan University
Aiwu Ke: Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Zhongshan Hospital, Fudan University
Haikun Wang: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Jianyong Ding: Zhongshan Hospital, Fudan University

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Thymoma is the most common tumor of the anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance imaging often lead to misdiagnosis between thymoma and other thymic abnormalities. Therefore, urgently needed is to develop a new diagnostic strategy. Here we identify interleukin-8 (IL-8) as a biomarker for auxiliary diagnosis of thymoma. We find that IL-8 levels in naïve T cells are markedly elevated in patients with thymoma compared to those with other thymic tumors. IL-8 levels in naive T cells are significantly decreased after surgical resection in thymoma patients, and rise again when thymoma recurs. A receiver operating characteristic curve analysis shows that IL-8 evaluation performs well in thymoma identification, with high specificities and sensitivities. We also observe significant clinical relevance between IL-8 levels in naïve T cells and clinicopathological features. In conclusion, our study suggests that IL-8 is a biomarker for thymoma identification and recurrence surveillance.

Date: 2020
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DOI: 10.1038/s41467-020-18697-x

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