Mycobacterium tuberculosis progresses through two phases of latent infection in humans

Roberto Colangeli, Aditi Gupta, Solange Alves Vinhas, Uma Deepthi Chippada Venkata, Soyeon Kim, Courtney Grady, Edward C. Jones-López, Patricia Soteropoulos, Moisés Palaci, Patrícia Marques-Rodrigues, Padmini Salgame, Jerrold J. Ellner, Reynaldo Dietze and David Alland ()
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Roberto Colangeli: Rutgers-New Jersey Medical School
Aditi Gupta: Rutgers-New Jersey Medical School
Solange Alves Vinhas: Universidade Federal do Espírito Santo (UFES)
Uma Deepthi Chippada Venkata: Rutgers-New Jersey Medical School
Soyeon Kim: Frontier Science Foundation
Courtney Grady: Rutgers-New Jersey Medical School
Edward C. Jones-López: University of Southern California Los Angeles
Patricia Soteropoulos: Rutgers-New Jersey Medical School
Moisés Palaci: Universidade Federal do Espírito Santo (UFES)
Patrícia Marques-Rodrigues: Universidade Federal do Espírito Santo (UFES)
Padmini Salgame: Rutgers-New Jersey Medical School
Jerrold J. Ellner: Rutgers-New Jersey Medical School
Reynaldo Dietze: Universidade Federal do Espírito Santo (UFES)
David Alland: Rutgers-New Jersey Medical School

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new mutations in the M. tuberculosis genome decline dramatically after two years of latent infection (two-sided p

Date: 2020
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DOI: 10.1038/s41467-020-18699-9

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