Fetal whole heart blood flow imaging using 4D cine MRI

Thomas A. Roberts (), Joshua F. P. Amerom, Alena Uus, David F. A. Lloyd, Milou P. M. Poppel, Anthony N. Price, Jacques-Donald Tournier, Chloe A. Mohanadass, Laurence H. Jackson, Shaihan J. Malik, Kuberan Pushparajah, Mary A. Rutherford, Reza Razavi, Maria Deprez and Joseph V. Hajnal
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Thomas A. Roberts: School of Biomedical Engineering & Imaging Sciences, King’s College London
Joshua F. P. Amerom: School of Biomedical Engineering & Imaging Sciences, King’s College London
Alena Uus: School of Biomedical Engineering & Imaging Sciences, King’s College London
David F. A. Lloyd: School of Biomedical Engineering & Imaging Sciences, King’s College London
Milou P. M. Poppel: School of Biomedical Engineering & Imaging Sciences, King’s College London
Anthony N. Price: School of Biomedical Engineering & Imaging Sciences, King’s College London
Jacques-Donald Tournier: School of Biomedical Engineering & Imaging Sciences, King’s College London
Chloe A. Mohanadass: School of Biomedical Engineering & Imaging Sciences, King’s College London
Laurence H. Jackson: School of Biomedical Engineering & Imaging Sciences, King’s College London
Shaihan J. Malik: School of Biomedical Engineering & Imaging Sciences, King’s College London
Kuberan Pushparajah: School of Biomedical Engineering & Imaging Sciences, King’s College London
Mary A. Rutherford: School of Biomedical Engineering & Imaging Sciences, King’s College London
Reza Razavi: School of Biomedical Engineering & Imaging Sciences, King’s College London
Maria Deprez: School of Biomedical Engineering & Imaging Sciences, King’s College London
Joseph V. Hajnal: School of Biomedical Engineering & Imaging Sciences, King’s College London

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Prenatal detection of congenital heart disease facilitates the opportunity for potentially life-saving care immediately after the baby is born. Echocardiography is routinely used for screening of morphological malformations, but functional measurements of blood flow are scarcely used in fetal echocardiography due to technical assumptions and issues of reliability. Magnetic resonance imaging (MRI) is readily used for quantification of abnormal blood flow in adult hearts, however, existing in utero approaches are compromised by spontaneous fetal motion. Here, we present and validate a novel method of MRI velocity-encoding combined with a motion-robust reconstruction framework for four-dimensional visualization and quantification of blood flow in the human fetal heart and major vessels. We demonstrate simultaneous 4D visualization of the anatomy and circulation, which we use to quantify flow rates through various major vessels. The framework introduced here could enable new clinical opportunities for assessment of the fetal cardiovascular system in both health and disease.

Date: 2020
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DOI: 10.1038/s41467-020-18790-1

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