Prevalent and sex-biased breathing patterns modify functional connectivity MRI in young adults

Charles J. Lynch, Benjamin M. Silver, Marc J. Dubin, Alex Martin, Henning U. Voss, Rebecca M. Jones and Jonathan D. Power ()
Additional contact information
Charles J. Lynch: Weill Cornell Medicine
Benjamin M. Silver: Weill Cornell Medicine
Marc J. Dubin: Weill Cornell Medicine
Alex Martin: National Institute of Mental Health
Henning U. Voss: Citigroup Biomedical Imaging Center
Rebecca M. Jones: Weill Cornell Medicine
Jonathan D. Power: Weill Cornell Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Resting state functional connectivity magnetic resonance imaging (fMRI) is a tool for investigating human brain organization. Here we identify, visually and algorithmically, two prevalent influences on fMRI signals during 440 h of resting state scans in 440 healthy young adults, both caused by deviations from normal breathing which we term deep breaths and bursts. The two respiratory patterns have distinct influences on fMRI signals and signal covariance, distinct timescales, distinct cardiovascular correlates, and distinct tendencies to manifest by sex. Deep breaths are not sex-biased. Bursts, which are serial taperings of respiratory depth typically spanning minutes at a time, are more common in males. Bursts share features of chemoreflex-driven clinical breathing patterns that also occur primarily in males, with notable neurological, psychiatric, medical, and lifespan associations. These results identify common breathing patterns in healthy young adults with distinct influences on functional connectivity and an ability to differentially influence resting state fMRI studies.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18974-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18974-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18974-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().