Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

Roberto Raschetti, Alexandre J. Vivanti, Christelle Vauloup-Fellous, Barbara Loi, Alexandra Benachi and Daniele De Luca ()
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Roberto Raschetti: Paris Saclay University Hospitals, APHP
Alexandre J. Vivanti: Paris Saclay University Hospitals, APHP
Christelle Vauloup-Fellous: Paris Saclay University Hospitals, APHP
Barbara Loi: Paris Saclay University Hospitals, APHP
Alexandra Benachi: Paris Saclay University Hospitals, APHP
Daniele De Luca: Paris Saclay University Hospitals, APHP

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6–16), p

Date: 2020
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DOI: 10.1038/s41467-020-18982-9

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