A high-stringency blueprint of the human proteome

Subash Adhikari, Edouard C. Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young-Ki Paik, Christopher M. Overall, Fernando J. Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua L. Justice, Joshua LaBaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C. S. Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P. Y. Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M. Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T. Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P. Snyder, Ruedi Aebersold and Mark S. Baker ()
Additional contact information
Subash Adhikari: Macquarie University
Edouard C. Nice: Macquarie University
Eric W. Deutsch: Institute for Systems Biology
Lydie Lane: University of Geneva, CMU
Gilbert S. Omenn: University of Michigan
Stephen R. Pennington: University College Dublin
Young-Ki Paik: Yonsei Proteome Research Center
Christopher M. Overall: University of British Columbia
Fernando J. Corrales: Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII
Ileana M. Cristea: Princeton University
Jennifer E. Van Eyk: The Smidt Heart Institute
Mathias Uhlén: KTH Royal Institute of Technology
Cecilia Lindskog: Uppsala University
Daniel W. Chan: Johns Hopkins University School of Medicine
Amos Bairoch: University of Geneva, CMU
James C. Waddington: University College Dublin
Joshua L. Justice: Princeton University
Joshua LaBaer: Arizona State University
Henry Rodriguez: National Cancer Institute, NIH
Fuchu He: Beijing Institute of Lifeomics
Markus Kostrzewa: Bruker Daltonik GmbH, Microbiology and Diagnostics
Peipei Ping: University of California Los Angeles
Rebekah L. Gundry: University of Nebraska Medical Center
Peter Stewart: Royal Prince Alfred Hospital
Sanjeeva Srivastava: Indian Institute of Technology Bombay
Sudhir Srivastava: National Institutes of Health
Fabio C. S. Nogueira: Federal University of Rio de Janeiro
Gilberto B. Domont: Federal University of Rio de Janeiro
Yves Vandenbrouck: University of Grenoble Alpes, Inserm, CEA, IRIG-BGE
Maggie P. Y. Lam: University of Colorado
Sara Wennersten: University of Colorado
Juan Antonio Vizcaino: European Bioinformatics Institute
Marc Wilkins: University of New South Wales
Jochen M. Schwenk: KTH Royal Institute of Technology
Emma Lundberg: KTH Royal Institute of Technology
Nuno Bandeira: University of California, San Diego
Gyorgy Marko-Varga: Lund University
Susan T. Weintraub: University of Texas Health Science Center San Antonio, UT Health
Charles Pineau: University of Rennes, Inserm, EHESP, IREST, UMR_S 1085
Ulrike Kusebauch: Institute for Systems Biology
Robert L. Moritz: Institute for Systems Biology
Seong Beom Ahn: Macquarie University
Magnus Palmblad: Leiden University Medical Center
Michael P. Snyder: Stanford School of Medicine
Ruedi Aebersold: Institute for Systems Biology
Mark S. Baker: Macquarie University

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Date: 2020
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DOI: 10.1038/s41467-020-19045-9

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