Increased RNA editing in maternal immune activation model of neurodevelopmental disease

Hadas Tsivion-Visbord, Eli Kopel, Ariel Feiglin, Tamar Sofer, Ran Barzilay, Tali Ben-Zur, Orly Yaron, Daniel Offen () and Erez Y. Levanon ()
Additional contact information
Hadas Tsivion-Visbord: Tel-Aviv University
Eli Kopel: Bar-Ilan University
Ariel Feiglin: Harvard Medical School
Tamar Sofer: Harvard University
Ran Barzilay: CHOP
Tali Ben-Zur: Tel-Aviv University
Orly Yaron: Bar-Ilan University
Daniel Offen: Tel-Aviv University
Erez Y. Levanon: Bar-Ilan University

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic PolyI:C infection during early gestation. We investigated the transcriptional changes in the brains of mouse fetuses following MIA during the prenatal period, and evaluated the behavioral and biochemical changes in the adult brain. The results reveal an increase in RNA editing levels and dysregulation in brain development-related gene pathways in the fetal brains of MIA mice. These MIA-induced brain editing changes are not observed in adulthood, although MIA-induced behavioral deficits are observed. Taken together, our findings suggest that MIA induces transient dysregulation of RNA editing at a critical time in brain development.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-19048-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19048-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-19048-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().