Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Antoni G. Wrobel (), Donald J. Benton (), Saira Hussain, Ruth Harvey, Stephen R. Martin, Chloë Roustan, Peter B. Rosenthal, John J. Skehel and Steven J. Gamblin ()
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Antoni G. Wrobel: Francis Crick Institute
Donald J. Benton: Francis Crick Institute
Saira Hussain: Francis Crick Institute
Ruth Harvey: Francis Crick Institute
Stephen R. Martin: Francis Crick Institute
Chloë Roustan: Francis Crick Institute
Peter B. Rosenthal: Francis Crick Institute
John J. Skehel: Francis Crick Institute
Steven J. Gamblin: Francis Crick Institute

Nature Communications, 2020, vol. 11, issue 1, 1-5

Abstract: Abstract The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

Date: 2020
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DOI: 10.1038/s41467-020-19146-5

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