Immune modulatory effects of oncogenic KRAS in cancer

Shaima’a Hamarsheh, Olaf Groß, Tilman Brummer and Robert Zeiser ()
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Shaima’a Hamarsheh: Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
Olaf Groß: Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
Tilman Brummer: Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg
Robert Zeiser: Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Oncogenic KRAS mutations are the most frequent mutations in human cancer, but most difficult to target. While sustained proliferation caused by oncogenic KRAS-downstream signalling is a main driver of carcinogenesis, there is increasing evidence that it also mediates autocrine effects and crosstalk with the tumour microenvironment (TME). Here, we discuss recent reports connecting KRAS mutations with tumour-promoting inflammation and immune modulation caused by KRAS that leads to immune escape in the TME. We discuss the preclinical work on KRAS-induced inflammation and immune modulation in the context of currently ongoing clinical trials targeting cancer entities that carry KRAS mutations and strategies to overcome the oncogene-induced effects on the immune system.

Date: 2020
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DOI: 10.1038/s41467-020-19288-6

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