Developmental divergence of sensory stimulus representation in cortical interneurons

Rahel Kastli, Rasmus Vighagen, Alexander Bourg, Ali Özgür Argunsah, Asim Iqbal, Fabian F. Voigt, Daniel Kirschenbaum, Adriano Aguzzi, Fritjof Helmchen and Theofanis Karayannis ()
Additional contact information
Rahel Kastli: University of Zurich, Winterthurerstrasse 190
Rasmus Vighagen: University of Zurich, Winterthurerstrasse 190
Alexander Bourg: University of Zurich, Winterthurerstrasse 190
Ali Özgür Argunsah: University of Zurich, Winterthurerstrasse 190
Asim Iqbal: University of Zurich, Winterthurerstrasse 190
Fabian F. Voigt: Winterthurerstrasse 190
Daniel Kirschenbaum: Winterthurerstrasse 190
Adriano Aguzzi: Winterthurerstrasse 190
Fritjof Helmchen: Winterthurerstrasse 190
Theofanis Karayannis: University of Zurich, Winterthurerstrasse 190

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Vasocative-intestinal-peptide (VIP+) and somatostatin (SST+) interneurons are involved in modulating barrel cortex activity and perception during active whisking. Here we identify a developmental transition point of structural and functional rearrangements onto these interneurons around the start of active sensation at P14. Using in vivo two-photon Ca2+ imaging, we find that before P14, both interneuron types respond stronger to a multi-whisker stimulus, whereas after P14 their responses diverge, with VIP+ cells losing their multi-whisker preference and SST+ neurons enhancing theirs. Additionally, we find that Ca2+ signaling dynamics increase in precision as the cells and network mature. Rabies virus tracings followed by tissue clearing, as well as photostimulation-coupled electrophysiology reveal that SST+ cells receive higher cross-barrel inputs compared to VIP+ neurons at both time points. In addition, whereas prior to P14 both cell types receive direct input from the sensory thalamus, after P14 VIP+ cells show reduced inputs and SST+ cells largely shift to motor-related thalamic nuclei.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-19427-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19427-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-19427-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().