Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Elisa M. Floriddia (), Tânia Lourenço, Shupei Zhang, David Bruggen, Markus M. Hilscher, Petra Kukanja, João P. Gonçalves dos Santos, Müge Altınkök, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mário Grãos, Lu O. Sun, Jonas Frisén, Mats Nilsson and Gonçalo Castelo-Branco ()
Additional contact information
Elisa M. Floriddia: Karolinska Institutet, Biomedicum
Tânia Lourenço: Karolinska Institutet, Biomedicum
Shupei Zhang: Karolinska Institutet, Biomedicum
David Bruggen: Karolinska Institutet, Biomedicum
Markus M. Hilscher: Stockholm University
Petra Kukanja: Karolinska Institutet, Biomedicum
João P. Gonçalves dos Santos: Karolinska Institutet, Biomedicum
Müge Altınkök: Karolinska Institutet, Biomedicum
Chika Yokota: Stockholm University
Enric Llorens-Bobadilla: Karolinska Institutet, Biomedicum
Sara B. Mulinyawe: Stanford University School of Medicine
Mário Grãos: Biocant, Technology Transfer Association
Lu O. Sun: Stanford University School of Medicine
Jonas Frisén: Karolinska Institutet, Biomedicum
Mats Nilsson: Stockholm University
Gonçalo Castelo-Branco: Karolinska Institutet, Biomedicum

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.

Date: 2020
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DOI: 10.1038/s41467-020-19453-x

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