Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Isabel Fernández-Pisonero, Begoña Porteiro, Christelle Veyrat-Durebex, Daniel Beiroa, Omar Al-Massadi, Antonio Abad, Carlos Diéguez, Roberto Coppari, Rubén Nogueiras and Xosé R. Bustelo ()
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Sonia Rodríguez-Fdez: CSIC-University of Salamanca
L. Francisco Lorenzo-Martín: CSIC-University of Salamanca
Isabel Fernández-Pisonero: CSIC-University of Salamanca
Begoña Porteiro: University of Santiago de Compostela
Christelle Veyrat-Durebex: University of Geneva
Daniel Beiroa: University of Santiago de Compostela
Omar Al-Massadi: University of Santiago de Compostela
Antonio Abad: CSIC-University of Salamanca
Carlos Diéguez: University of Santiago de Compostela
Roberto Coppari: University of Geneva
Rubén Nogueiras: University of Santiago de Compostela
Xosé R. Bustelo: CSIC-University of Salamanca

Nature Communications, 2020, vol. 11, issue 1, 1-26

Abstract: Abstract Skeletal muscle promotes metabolic balance by regulating glucose uptake and the stimulation of multiple interorgan crosstalk. We show here that the catalytic activity of Vav2, a Rho GTPase activator, modulates the signaling output of the IGF1- and insulin-stimulated phosphatidylinositol 3-kinase pathway in that tissue. Consistent with this, mice bearing a Vav2 protein with decreased catalytic activity exhibit reduced muscle mass, lack of proper insulin responsiveness and, at much later times, a metabolic syndrome-like condition. Conversely, mice expressing a catalytically hyperactive Vav2 develop muscle hypertrophy and increased insulin responsiveness. Of note, while hypoactive Vav2 predisposes to, hyperactive Vav2 protects against high fat diet-induced metabolic imbalance. These data unveil a regulatory layer affecting the signaling output of insulin family factors in muscle.

Date: 2020
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DOI: 10.1038/s41467-020-19489-z

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