Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut

Leszek Michalak, John Christian Gaby (), Leidy Lagos, Sabina Leanti Rosa, Torgeir R. Hvidsten, Catherine Tétard-Jones, William G. T. Willats, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Johannes Dröge, Magnus Øverlie Arntzen, Live Heldal Hagen, Margareth Øverland, Phillip B. Pope () and Bjørge Westereng ()
Additional contact information
Leszek Michalak: Norwegian University of Life Sciences
John Christian Gaby: Norwegian University of Life Sciences
Leidy Lagos: Norwegian University of Life Sciences
Sabina Leanti Rosa: Norwegian University of Life Sciences
Torgeir R. Hvidsten: Norwegian University of Life Sciences
Catherine Tétard-Jones: Newcastle University
William G. T. Willats: Newcastle University
Nicolas Terrapon: Aix-Marseille Université
Vincent Lombard: Aix-Marseille Université
Bernard Henrissat: Aix-Marseille Université
Johannes Dröge: Chalmers University of Technology
Magnus Øverlie Arntzen: Norwegian University of Life Sciences
Live Heldal Hagen: Norwegian University of Life Sciences
Margareth Øverland: Norwegian University of Life Sciences
Phillip B. Pope: Norwegian University of Life Sciences
Bjørge Westereng: Norwegian University of Life Sciences

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Beneficial modulation of the gut microbiome has high-impact implications not only in humans, but also in livestock that sustain our current societal needs. In this context, we have tailored an acetylated galactoglucomannan (AcGGM) fibre to match unique enzymatic capabilities of Roseburia and Faecalibacterium species, both renowned butyrate-producing gut commensals. Here, we test the accuracy of AcGGM within the complex endogenous gut microbiome of pigs, wherein we resolve 355 metagenome-assembled genomes together with quantitative metaproteomes. In AcGGM-fed pigs, both target populations differentially express AcGGM-specific polysaccharide utilization loci, including novel, mannan-specific esterases that are critical to its deconstruction. However, AcGGM-inclusion also manifests a “butterfly effect”, whereby numerous metabolic changes and interdependent cross-feeding pathways occur in neighboring non-mannanolytic populations that produce short-chain fatty acids. Our findings show how intricate structural features and acetylation patterns of dietary fibre can be customized to specific bacterial populations, with potential to create greater modulatory effects at large.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-19585-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19585-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-19585-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().