Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming

Seongbeom Kim, Chi-Yeol Kim, Sook-Young Park, Ki-Tae Kim, Jongbum Jeon, Hyunjung Chung, Gobong Choi, Seomun Kwon, Jaeyoung Choi, Junhyun Jeon, Jong-Seong Jeon, Chang Hyun Khang, Seogchan Kang and Yong-Hwan Lee ()
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Seongbeom Kim: Seoul National University
Chi-Yeol Kim: Seoul National University
Sook-Young Park: Sunchon National University
Ki-Tae Kim: Seoul National University
Jongbum Jeon: Seoul National University
Hyunjung Chung: Seoul National University
Gobong Choi: Seoul National University
Seomun Kwon: Seoul National University
Jaeyoung Choi: Seoul National University
Junhyun Jeon: Yeungnam University
Jong-Seong Jeon: Kyung Hee University
Chang Hyun Khang: University of Georgia
Seogchan Kang: The Pennsylvania State University
Yong-Hwan Lee: Seoul National University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Pathogens utilize multiple types of effectors to modulate plant immunity. Although many apoplastic and cytoplasmic effectors have been reported, nuclear effectors have not been well characterized in fungal pathogens. Here, we characterize two nuclear effectors of the rice blast pathogen Magnaporthe oryzae. Both nuclear effectors are secreted via the biotrophic interfacial complex, translocated into the nuclei of initially penetrated and surrounding cells, and reprogram the expression of immunity-associated genes by binding on effector binding elements in rice. Their expression in transgenic rice causes ambivalent immunity: increased susceptibility to M. oryzae and Xanthomonas oryzae pv. oryzae, hemibiotrophic pathogens, but enhanced resistance to Cochliobolus miyabeanus, a necrotrophic pathogen. Our findings help remedy a significant knowledge deficiency in the mechanism of M. oryzae–rice interactions and underscore how effector-mediated manipulation of plant immunity by one pathogen may also affect the disease severity by other pathogens.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19624-w

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DOI: 10.1038/s41467-020-19624-w

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