Plasmonic nano-aperture label-free imaging (PANORAMA)

Nareg Ohannesian, Ibrahim Misbah, Steven H. Lin and Wei-Chuan Shih ()
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Nareg Ohannesian: University of Houston
Ibrahim Misbah: University of Houston
Steven H. Lin: The University of Texas MD Anderson Cancer Center
Wei-Chuan Shih: University of Houston

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Label-free optical imaging of nanoscale objects faces fundamental challenges. Techniques based on propagating surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) have shown promises. However, challenges remain to achieve diffraction-limited resolution and better surface localization in SPR imaging. LSPR imaging with dark-field microscopy on metallic nanostructures suffers from low light throughput and insufficient imaging capacity. Here we show ultra-near-field index modulated PlAsmonic NanO-apeRture lAbel-free iMAging (PANORAMA) which uniquely relies on unscattered light to detect sub-100 nm dielectric nanoparticles. PANORAMA provides diffraction-limited resolution, higher surface sensitivity, and wide-field imaging with dense spatial sampling. Its system is identical to a standard bright-field microscope with a lamp and a camera – no laser or interferometry is needed. In a parallel fashion, PANORAMA can detect, count and size individual dielectric nanoparticles beyond 25 nm, and dynamically monitor their distance to the plasmonic surface at millisecond timescale.

Date: 2020
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DOI: 10.1038/s41467-020-19678-w

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