Genome-enabled discovery of anthraquinone biosynthesis in Senna tora

Sang-Ho Kang (), Ramesh Prasad Pandey, Chang-Muk Lee, Joon-Soo Sim, Jin-Tae Jeong, Beom-Soon Choi, Myunghee Jung, Daniel Ginzburg, Kangmei Zhao, So Youn Won, Tae-Jin Oh, Yeisoo Yu, Nam-Hoon Kim, Ok Ran Lee, Tae-Ho Lee, Puspalata Bashyal, Tae-Su Kim, Woo-Haeng Lee, Charles Hawkins, Chang-Kug Kim, Jung Sun Kim, Byoung Ohg Ahn, Seung Yon Rhee () and Jae Kyung Sohng ()
Additional contact information
Sang-Ho Kang: Genomics Division, National Institute of Agricultural Sciences, RDA
Ramesh Prasad Pandey: Sun Moon University
Chang-Muk Lee: Metabolic Engineering Division, National Institute of Agricultural Sciences, RDA
Joon-Soo Sim: Metabolic Engineering Division, National Institute of Agricultural Sciences, RDA
Jin-Tae Jeong: National Institute of Horticultural and Herbal Science, RDA
Beom-Soon Choi: Phyzen Genomics Institute
Myunghee Jung: Seoul National University
Daniel Ginzburg: Carnegie Institution for Science
Kangmei Zhao: Carnegie Institution for Science
So Youn Won: Genomics Division, National Institute of Agricultural Sciences, RDA
Tae-Jin Oh: Sun Moon University
Yeisoo Yu: Phyzen Genomics Institute
Nam-Hoon Kim: Phyzen Genomics Institute
Ok Ran Lee: Chonnam National University
Tae-Ho Lee: Genomics Division, National Institute of Agricultural Sciences, RDA
Puspalata Bashyal: Sun Moon University
Tae-Su Kim: Sun Moon University
Woo-Haeng Lee: Sun Moon University
Charles Hawkins: Carnegie Institution for Science
Chang-Kug Kim: Genomics Division, National Institute of Agricultural Sciences, RDA
Jung Sun Kim: Genomics Division, National Institute of Agricultural Sciences, RDA
Byoung Ohg Ahn: Genomics Division, National Institute of Agricultural Sciences, RDA
Seung Yon Rhee: Carnegie Institution for Science
Jae Kyung Sohng: Sun Moon University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.

Date: 2020
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DOI: 10.1038/s41467-020-19681-1

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