Immune suppression in the early stage of COVID-19 disease

Wenmin Tian, Nan Zhang, Ronghua Jin, Yingmei Feng, Siyuan Wang, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Di Tian, Wenjie Tan (), Yang Chen (), George Fu Gao () and Catherine C. L. Wong ()
Additional contact information
Wenmin Tian: Peking University
Nan Zhang: Peking University
Ronghua Jin: Capital Medical University
Yingmei Feng: Capital Medical University
Siyuan Wang: Peking University
Shuaixin Gao: Peking University
Ruqin Gao: Qingdao Municipal Center for Disease Control and Prevention
Guizhen Wu: Chinese Center for Disease Control and Prevention (China CDC)
Di Tian: Capital Medical University
Wenjie Tan: Chinese Center for Disease Control and Prevention (China CDC)
Yang Chen: Peking University
George Fu Gao: Chinese Center for Disease Control and Prevention (China CDC)
Catherine C. L. Wong: Peking University

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-19706-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19706-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-19706-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().