Neonicotinoid Clothianidin reduces honey bee immune response and contributes to Varroa mite proliferation

Desiderato Annoscia, Gennaro Di Prisco, Andrea Becchimanzi, Emilio Caprio, Davide Frizzera, Alberto Linguadoca, Francesco Nazzi () and Francesco Pennacchio ()
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Desiderato Annoscia: Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine
Gennaro Di Prisco: Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
Andrea Becchimanzi: Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
Emilio Caprio: Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
Davide Frizzera: Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine
Alberto Linguadoca: Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”
Francesco Nazzi: Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine
Francesco Pennacchio: Dipartimento di Agraria, Laboratorio di Entomologia “E. Tremblay”, Università degli Studi di Napoli “Federico II”

Nature Communications, 2020, vol. 11, issue 1, 1-7

Abstract: Abstract The neonicotinoid Clothianidin has a negative impact on NF-κB signaling and on immune responses controlled by this transcription factor, which can boost the proliferation of honey bee parasites and pathogens. This effect has been well documented for the replication of deformed wing virus (DWV) induced by Clothianidin in honey bees bearing an asymptomatic infection. Here, we conduct infestation experiments of treated bees to show that the immune-suppression exerted by Clothianidin is associated with an enhanced fertility of the parasitic mite Varroa destructor, as a possible consequence of a higher feeding efficiency. A conceptual model is proposed to describe the synergistic interactions among different stress agents acting on honey bees.

Date: 2020
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DOI: 10.1038/s41467-020-19715-8

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