Diffuse neural coupling mediates complex network dynamics through the formation of quasi-critical brain states

Eli J. Müller (), Brandon R. Munn and James M. Shine
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Eli J. Müller: The University of Sydney
Brandon R. Munn: The University of Sydney
James M. Shine: The University of Sydney

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract The biological mechanisms that allow the brain to balance flexibility and integration remain poorly understood. A potential solution may lie in a unique aspect of neurobiology, which is that numerous brain systems contain diffuse synaptic connectivity. Here, we demonstrate that increasing diffuse cortical coupling within a validated biophysical corticothalamic model traverses the system through a quasi-critical regime in which spatial heterogeneities in input noise support transient critical dynamics in distributed subregions. The presence of quasi-critical states coincides with known signatures of complex, adaptive brain network dynamics. Finally, we demonstrate the presence of similar dynamic signatures in empirical whole-brain human neuroimaging data. Together, our results establish that modulating the balance between local and diffuse synaptic coupling in a thalamocortical model subtends the emergence of quasi-critical brain states that act to flexibly transition the brain between unique modes of information processing.

Date: 2020
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DOI: 10.1038/s41467-020-19716-7

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