Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

Haithem Barbour, Salima Daou, Michael Hendzel and El Bachir Affar ()
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Haithem Barbour: University of Montréal
Salima Daou: University of Montréal
Michael Hendzel: University of Alberta, Room 3332 Cross Cancer Institute, 11560 University Avenue NW
El Bachir Affar: University of Montréal

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex. Here we critically assess the current knowledge regarding H2Aub deposition and removal, its crosstalk with PcG repressive complex 2 (PRC2)-mediated histone H3K27 methylation, and the recent attempts toward discovering its readers and solving its enigmatic functions. We also discuss mounting evidence of the involvement of H2A ubiquitination in human pathologies including cancer, while highlighting some knowledge gaps that remain to be addressed.

Date: 2020
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DOI: 10.1038/s41467-020-19722-9

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