Proton-enabled activation of peptide materials for biological bimodal memory

Min-Kyu Song, Seok Daniel Namgung, Daehwan Choi, Hyeohn Kim, Hongmin Seo, Misong Ju, Yoon Ho Lee, Taehoon Sung, Yoon-Sik Lee, Ki Tae Nam () and Jang-Yeon Kwon ()
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Min-Kyu Song: Yonsei University
Seok Daniel Namgung: Seoul National University
Daehwan Choi: Yonsei University
Hyeohn Kim: Seoul National University
Hongmin Seo: Seoul National University
Misong Ju: Seoul National University
Yoon Ho Lee: Seoul National University
Taehoon Sung: Yonsei University
Yoon-Sik Lee: Seoul National University
Ki Tae Nam: Seoul National University
Jang-Yeon Kwon: Yonsei University

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract The process of memory and learning in biological systems is multimodal, as several kinds of input signals cooperatively determine the weight of information transfer and storage. This study describes a peptide-based platform of materials and devices that can control the coupled conduction of protons and electrons and thus create distinct regions of synapse-like performance depending on the proton activity. We utilized tyrosine-rich peptide-based films and generalized our principles by demonstrating both memristor and synaptic devices. Interestingly, even memristive behavior can be controlled by both voltage and humidity inputs, learning and forgetting process in the device can be initiated and terminated by protons alone in peptide films. We believe that this work can help to understand the mechanism of biological memory and lay a foundation to realize a brain-like device based on ions and electrons.

Date: 2020
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DOI: 10.1038/s41467-020-19750-5

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