Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

Mark J. Siedner (), Michelle A. Moorhouse, Bryony Simmons, Tulio Oliveira, Richard Lessells, Jennifer Giandhari, Stephen A. Kemp, Benjamin Chimukangara, Godspower Akpomiemie, Celicia M. Serenata, Willem D. F. Venter, Andrew Hill and Ravindra K. Gupta ()
Additional contact information
Mark J. Siedner: Africa Health Research Institute
Michelle A. Moorhouse: University of Witwatersrand
Bryony Simmons: Imperial College
Tulio Oliveira: University of KwaZulu-Natal
Richard Lessells: University of KwaZulu-Natal
Jennifer Giandhari: University of KwaZulu-Natal
Stephen A. Kemp: University of Cambridge
Benjamin Chimukangara: University of KwaZulu-Natal
Godspower Akpomiemie: University of Witwatersrand
Celicia M. Serenata: University of Witwatersrand
Willem D. F. Venter: University of Witwatersrand
Andrew Hill: University of Liverpool
Ravindra K. Gupta: Africa Health Research Institute

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262). Our primary outcome was 96-week virologic success, defined as a sustained viral load

Date: 2020
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DOI: 10.1038/s41467-020-19801-x

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