Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

Shiyi Cao, Yong Gan, Chao Wang, Max Bachmann, Shanbo Wei, Jie Gong, Yuchai Huang, Tiantian Wang, Liqing Li, Kai Lu, Heng Jiang, Yanhong Gong, Hongbin Xu, Xin Shen, Qingfeng Tian, Chuanzhu Lv (), Fujian Song (), Xiaoxv Yin () and Zuxun Lu ()
Additional contact information
Shiyi Cao: Huazhong University of Science and Technology
Yong Gan: Huazhong University of Science and Technology
Chao Wang: Huazhong University of Science and Technology
Max Bachmann: University of East Anglia
Shanbo Wei: Wuhan Municipal Health Commission
Jie Gong: Wuhan Centre for Clinical Laboratory
Yuchai Huang: Huazhong University of Science and Technology
Tiantian Wang: Huazhong University of Science and Technology
Liqing Li: Jiangxi Science and Technology Normal University
Kai Lu: Huazhong University of Science and Technology
Heng Jiang: La Trobe University
Yanhong Gong: Huazhong University of Science and Technology
Hongbin Xu: Huazhong University of Science and Technology
Xin Shen: Huazhong University of Science and Technology
Qingfeng Tian: School of Public Health, Zhengzhou University
Chuanzhu Lv: The Second Affiliated Hospital of Hainan Medical University
Fujian Song: University of East Anglia
Xiaoxv Yin: Huazhong University of Science and Technology
Zuxun Lu: Huazhong University of Science and Technology

Nature Communications, 2020, vol. 11, issue 1, 1-7

Abstract: Abstract Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown.

Date: 2020
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DOI: 10.1038/s41467-020-19802-w

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