Spatially expandable fiber-based probes as a multifunctional deep brain interface

Shan Jiang, Dipan C. Patel, Jongwoon Kim, Shuo Yang, William A. Mills, Yujing Zhang, Kaiwen Wang, Ziang Feng, Sujith Vijayan, Wenjun Cai, Anbo Wang, Yuanyuan Guo, Ian F. Kimbrough, Harald Sontheimer and Xiaoting Jia ()
Additional contact information
Shan Jiang: Bradley Department of Electrical and Computer Engineering, Virginia Tech
Dipan C. Patel: Fralin Biomedical Research Institute
Jongwoon Kim: Bradley Department of Electrical and Computer Engineering, Virginia Tech
Shuo Yang: Bradley Department of Electrical and Computer Engineering, Virginia Tech
William A. Mills: Translational Biology, Medicine, and Health, Virginia Tech
Yujing Zhang: Bradley Department of Electrical and Computer Engineering, Virginia Tech
Kaiwen Wang: Department of Materials Science and Engineering, Virginia Tech
Ziang Feng: Bradley Department of Electrical and Computer Engineering, Virginia Tech
Sujith Vijayan: School of Neuroscience, Virginia Tech
Wenjun Cai: Department of Materials Science and Engineering, Virginia Tech
Anbo Wang: Bradley Department of Electrical and Computer Engineering, Virginia Tech
Yuanyuan Guo: Frontier Research Institute of Interdisciplinary Science (FRIS), Tohoku University
Ian F. Kimbrough: School of Neuroscience, Virginia Tech
Harald Sontheimer: Fralin Biomedical Research Institute
Xiaoting Jia: Bradley Department of Electrical and Computer Engineering, Virginia Tech

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Understanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires miniaturized neural interfaces that integrate into brain tissue without altering its properties. Existing neural interface technologies have been shown to provide high-resolution electrophysiological recording with high signal-to-noise ratio. However, with single implantation, the physical properties of these devices limit their access to one, small brain region. To overcome this limitation, we developed a platform that provides three-dimensional coverage of brain tissue through multisite multifunctional fiber-based neural probes guided in a helical scaffold. Chronic recordings from the spatially expandable fiber probes demonstrate the ability of these fiber probes capturing brain activities with a single-unit resolution for long observation times. Furthermore, using Thy1-ChR2-YFP mice we demonstrate the application of our probes in simultaneous recording and optical/chemical modulation of brain activities across distant regions. Similarly, varying electrographic brain activities from different brain regions were detected by our customizable probes in a mouse model of epilepsy, suggesting the potential of using these probes for the investigation of brain disorders such as epilepsy. Ultimately, this technique enables three-dimensional manipulation and mapping of brain activities across distant regions in the deep brain with minimal tissue damage, which can bring new insights for deciphering complex brain functions and dynamics in the near future.

Date: 2020
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DOI: 10.1038/s41467-020-19946-9

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