Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

Yubo Wang, Jose Enrico Q. Quinsaat, Tomoko Ono, Masatoshi Maeki, Manabu Tokeshi, Takuya Isono, Kenji Tajima, Toshifumi Satoh, Shin-ichiro Sato, Yutaka Miura and Takuya Yamamoto ()
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Yubo Wang: Hokkaido University
Jose Enrico Q. Quinsaat: Hokkaido University
Tomoko Ono: Hokkaido University
Masatoshi Maeki: Hokkaido University
Manabu Tokeshi: Hokkaido University
Takuya Isono: Hokkaido University
Kenji Tajima: Hokkaido University
Toshifumi Satoh: Hokkaido University
Shin-ichiro Sato: Hokkaido University
Yutaka Miura: The University of Tokyo
Takuya Yamamoto: Hokkaido University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent stabilization for the surface-modification of gold nanoparticles (AuNPs) through physisorption. By simply mixing c-PEG, but not linear counterparts, enables AuNPs to maintain dispersibility through freezing, lyophilization, or heating. Surprisingly, c-PEG endowed AuNPs with even better dispersion stability than thiolated PEG (HS–PEG–OMe). The stronger affinity of c-PEG was confirmed by DLS, ζ-potential, and FT-IR. Furthermore, the c-PEG system exhibited prolonged blood circulation and enhanced tumor accumulation in mice. Our data suggests that c-PEG induces physisorption on AuNPs, supplying sufficient stability toward bio-medical applications, and would be an alternative approach to the gold–sulfur chemisorption.

Date: 2020
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DOI: 10.1038/s41467-020-19947-8

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