Using antibodies to control DNA-templated chemical reactions

Lorena Baranda Pellejero, Malihe Mahdifar, Gianfranco Ercolani, Jonathan Watson, Tom Brown and Francesco Ricci ()
Additional contact information
Lorena Baranda Pellejero: University of Rome, Tor Vergata, Via della Ricerca Scientifica
Malihe Mahdifar: University of Rome, Tor Vergata, Via della Ricerca Scientifica
Gianfranco Ercolani: University of Rome, Tor Vergata, Via della Ricerca Scientifica
Jonathan Watson: ATDBio Ltd, Magdalen Centre, Oxford Science Park
Tom Brown: ATDBio Ltd, Magdalen Centre, Oxford Science Park
Francesco Ricci: University of Rome, Tor Vergata, Via della Ricerca Scientifica

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract DNA-templated synthesis takes advantage of the programmability of DNA-DNA interactions to accelerate chemical reactions under diluted conditions upon sequence-specific hybridization. While this strategy has proven advantageous for a variety of applications, including sensing and drug discovery, it has been so far limited to the use of nucleic acids as templating elements. Here, we report the rational design of DNA templated synthesis controlled by specific IgG antibodies. Our approach is based on the co-localization of reactants induced by the bivalent binding of a specific IgG antibody to two antigen-conjugated DNA templating strands that triggers a chemical reaction that would be otherwise too slow under diluted conditions. This strategy is versatile, orthogonal and adaptable to different IgG antibodies and can be employed to achieve the targeted synthesis of clinically-relevant molecules in the presence of specific IgG biomarker antibodies.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-20024-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-20024-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-20024-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().