High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination

Guoqiang Liu, Yuan Zeng, Tong Lv, Tengfei Mao, Yen Wei, Shunji Jia, Yanzi Gou and Lei Tao ()
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Guoqiang Liu: Tsinghua University
Yuan Zeng: Tsinghua University
Tong Lv: Tsinghua University
Tengfei Mao: Tsinghua University
Yen Wei: Tsinghua University
Shunji Jia: Tsinghua University
Yanzi Gou: National University of Defense Technology
Lei Tao: Tsinghua University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch’s reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers.

Date: 2020
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DOI: 10.1038/s41467-020-20027-0

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