Myonuclear content regulates cell size with similar scaling properties in mice and humans

Kenth-Arne Hansson, Einar Eftestøl, Jo C. Bruusgaard, Inga Juvkam, Alyssa W. Cramer, Anders Malthe-Sørenssen, Douglas P. Millay and Kristian Gundersen ()
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Kenth-Arne Hansson: University of Oslo
Einar Eftestøl: University of Oslo
Jo C. Bruusgaard: University of Oslo
Inga Juvkam: University of Oslo
Alyssa W. Cramer: Cincinnati Children’s Hospital Medical Center
Anders Malthe-Sørenssen: University of Oslo
Douglas P. Millay: Cincinnati Children’s Hospital Medical Center
Kristian Gundersen: University of Oslo

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number (N) adheres to the relationship N = aVb where V is the cytoplasmic volume. N invariably scales sublinearly to V (b

Date: 2020
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DOI: 10.1038/s41467-020-20057-8

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