Whole-genome sequencing analysis of the cardiometabolic proteome

Arthur Gilly, Young-Chan Park, Grace Png, Andrei Barysenka, Iris Fischer, Thea Bjørnland, Lorraine Southam, Daniel Suveges, Sonja Neumeyer, N. William Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis and Eleftheria Zeggini ()
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Arthur Gilly: Helmholtz Zentrum München—German Research Center for Environmental Health
Young-Chan Park: Wellcome Genome Campus
Grace Png: Helmholtz Zentrum München—German Research Center for Environmental Health
Andrei Barysenka: Helmholtz Zentrum München—German Research Center for Environmental Health
Iris Fischer: Helmholtz Zentrum München—German Research Center for Environmental Health
Thea Bjørnland: Wellcome Genome Campus
Lorraine Southam: Helmholtz Zentrum München—German Research Center for Environmental Health
Daniel Suveges: Wellcome Genome Campus
Sonja Neumeyer: Helmholtz Zentrum München—German Research Center for Environmental Health
N. William Rayner: Helmholtz Zentrum München—German Research Center for Environmental Health
Emmanouil Tsafantakis: Anogia Medical Centre
Maria Karaleftheri: Echinos Medical Centre
George Dedoussis: Harokopio University of Athens
Eleftheria Zeggini: Helmholtz Zentrum München—German Research Center for Environmental Health

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257 circulating protein biomarkers of cardiometabolic relevance through high-depth (22.5×) whole-genome sequencing (WGS) in 1328 individuals. We discover 131 independent sequence variant associations (P

Date: 2020
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DOI: 10.1038/s41467-020-20079-2

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