Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

Carmen Lidia Diaz Soria, Jayhun Lee, Tracy Chong, Avril Coghlan, Alan Tracey, Matthew D. Young, Tallulah Andrews, Christopher Hall, Bee Ling Ng, Kate Rawlinson, Stephen R. Doyle, Steven Leonard, Zhigang Lu, Hayley M. Bennett, Gabriel Rinaldi (), Phillip A. Newmark () and Matthew Berriman ()
Additional contact information
Carmen Lidia Diaz Soria: Wellcome Genome Campus
Jayhun Lee: Morgridge Institute for Research
Tracy Chong: Morgridge Institute for Research
Avril Coghlan: Wellcome Genome Campus
Alan Tracey: Wellcome Genome Campus
Matthew D. Young: Wellcome Genome Campus
Tallulah Andrews: Wellcome Genome Campus
Christopher Hall: Wellcome Genome Campus
Bee Ling Ng: Wellcome Genome Campus
Kate Rawlinson: Wellcome Genome Campus
Stephen R. Doyle: Wellcome Genome Campus
Steven Leonard: Wellcome Genome Campus
Zhigang Lu: Wellcome Genome Campus
Hayley M. Bennett: Wellcome Genome Campus
Gabriel Rinaldi: Wellcome Genome Campus
Phillip A. Newmark: Morgridge Institute for Research
Matthew Berriman: Wellcome Genome Campus

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract Over 250 million people suffer from schistosomiasis, a tropical disease caused by parasitic flatworms known as schistosomes. Humans become infected by free-swimming, water-borne larvae, which penetrate the skin. The earliest intra-mammalian stage, called the schistosomulum, undergoes a series of developmental transitions. These changes are critical for the parasite to adapt to its new environment as it navigates through host tissues to reach its niche, where it will grow to reproductive maturity. Unravelling the mechanisms that drive intra-mammalian development requires knowledge of the spatial organisation and transcriptional dynamics of different cell types that comprise the schistomulum body. To fill these important knowledge gaps, we perform single-cell RNA sequencing on two-day old schistosomula of Schistosoma mansoni. We identify likely gene expression profiles for muscle, nervous system, tegument, oesophageal gland, parenchymal/primordial gut cells, and stem cells. In addition, we validate cell markers for all these clusters by in situ hybridisation in schistosomula and adult parasites. Taken together, this study provides a comprehensive cell-type atlas for the early intra-mammalian stage of this devastating metazoan parasite.

Date: 2020
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DOI: 10.1038/s41467-020-20092-5

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