The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences

Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pei-Sze Ng, Mei-Yee Meng, Siti Norhidayu Hasan, Bethan Sandey, Stephen-John Sammut, Cheng-Har Yip, Pathmanathan Rajadurai, Oscar M. Rueda, Carlos Caldas, Suet-Feung Chin () and Soo-Hwang Teo ()
Additional contact information
Jia-Wern Pan: No. 1
Muhammad Mamduh Ahmad Zabidi: No. 1
Pei-Sze Ng: No. 1
Mei-Yee Meng: No. 1
Siti Norhidayu Hasan: No. 1
Bethan Sandey: Li Ka Shing Centre, Robinson Way
Stephen-John Sammut: Li Ka Shing Centre, Robinson Way
Cheng-Har Yip: University Malaya
Pathmanathan Rajadurai: Subang Jaya Medical Centre
Oscar M. Rueda: Li Ka Shing Centre, Robinson Way
Carlos Caldas: Li Ka Shing Centre, Robinson Way
Suet-Feung Chin: Li Ka Shing Centre, Robinson Way
Soo-Hwang Teo: No. 1

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain understudied. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women. Compared to breast tumours in Caucasian women, we show an increased prevalence of HER2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumours. We also observe elevated immune scores in Asian breast tumours, suggesting potential clinical response to immune checkpoint inhibitors. Whilst HER2-subtype and enriched immune score are associated with improved survival, presence of TP53 somatic mutations is associated with poorer survival in ER+ tumours. Taken together, these population differences unveil opportunities to improve the understanding of this disease and lay the foundation for precision medicine in different populations.

Date: 2020
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DOI: 10.1038/s41467-020-20173-5

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