Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

Zhusheng Huang, Yuxiang Wang, Dan Yao, Jinhui Wu, Yiqiao Hu () and Ahu Yuan ()
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Zhusheng Huang: Nanjing University
Yuxiang Wang: Nanjing University
Dan Yao: Nanjing University
Jinhui Wu: Nanjing University
Yiqiao Hu: Nanjing University
Ahu Yuan: Nanjing University

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Radiation therapy can potentially induce immunogenic cell death, thereby priming anti-tumor adaptive immune responses. However, radiation-induced systemic immune responses are very rare and insufficient to meet clinical needs. Here, we demonstrate a synergetic strategy for boosting radiation-induced immunogenic cell death by constructing gadolinium-hemin based nanoscale coordination polymers to simultaneously perform X-ray deposition and glutathione depletion. Subsequently, immunogenic cell death is induced by sensitized radiation to potentiate checkpoint blockade immunotherapies against primary and metastatic tumors. In conclusion, nanoscale coordination polymers-sensitized radiation therapy exhibits biocompatibility and therapeutic efficacy in preclinical cancer models, and has the potential for further application in cancer radio-immunotherapy.

Date: 2021
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DOI: 10.1038/s41467-020-20243-8

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