Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus

Lin Que, David Lukacsovich, Wenshu Luo and Csaba Földy ()
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Lin Que: University of Zürich
David Lukacsovich: University of Zürich
Wenshu Luo: University of Zürich
Csaba Földy: University of Zürich

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited the identification of several known cell types. In this study, we used single-cell RNA-seq in morphologically identified parvalbumin interneurons (PV-INs), and studied their transcriptomic states in the morphological, physiological, and developmental domains. Overall, we find high transcriptomic similarity among PV-INs, with few genes showing divergent expression between morphologically different types. Furthermore, PV-INs show a uniform synaptic cell adhesion molecule (CAM) profile, suggesting that CAM expression in mature PV cells does not reflect wiring specificity after development. Together, our results suggest that while PV-INs differ in anatomy and in vivo activity, their continuous transcriptomic and homogenous biophysical landscapes are not predictive of these distinct identities.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20328-4

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DOI: 10.1038/s41467-020-20328-4

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