Longitudinal evaluation of fecal microbiota transplantation for ameliorating calf diarrhea and improving growth performance

Hyun Sik Kim, Tae Woong Whon, Hojun Sung, Yun-Seok Jeong, Eun Sung Jung, Na-Ri Shin, Dong-Wook Hyun, Pil Soo Kim, June-Young Lee, Choong Hwan Lee and Jin-Woo Bae ()
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Hyun Sik Kim: Kyung Hee University
Tae Woong Whon: Kyung Hee University
Hojun Sung: Kyung Hee University
Yun-Seok Jeong: Kyung Hee University
Eun Sung Jung: Konkuk University
Na-Ri Shin: Kyung Hee University
Dong-Wook Hyun: Kyung Hee University
Pil Soo Kim: Kyung Hee University
June-Young Lee: Kyung Hee University
Choong Hwan Lee: Konkuk University
Jin-Woo Bae: Kyung Hee University

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Calf diarrhea is associated with enteric infections, and also provokes the overuse of antibiotics. Therefore, proper treatment of diarrhea represents a therapeutic challenge in livestock production and public health concerns. Here, we describe the ability of a fecal microbiota transplantation (FMT), to ameliorate diarrhea and restore gut microbial composition in 57 growing calves. We conduct multi-omics analysis of 450 longitudinally collected fecal samples and find that FMT-induced alterations in the gut microbiota (an increase in the family Porphyromonadaceae) and metabolomic profile (a reduction in fecal amino acid concentration) strongly correlate with the remission of diarrhea. During the continuous follow-up study over 24 months, we find that FMT improves the growth performance of the cattle. This first FMT trial in ruminants suggest that FMT is capable of ameliorating diarrhea in pre-weaning calves with alterations in their gut microbiota, and that FMT may have a potential role in the improvement of growth performance.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20389-5

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DOI: 10.1038/s41467-020-20389-5

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