Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

Woo Seok Kim, Sungcheol Hong, Milenka Gamero, Vivekanand Jeevakumar, Clay M. Smithhart, Theodore J. Price, Richard D. Palmiter (), Carlos Campos () and Sung Il Park ()
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Woo Seok Kim: Texas A&M University
Sungcheol Hong: Texas A&M University
Milenka Gamero: Texas A&M University
Vivekanand Jeevakumar: The University of Texas at Dallas
Clay M. Smithhart: The University of Texas at Dallas
Theodore J. Price: The University of Texas at Dallas
Richard D. Palmiter: University of Washington
Carlos Campos: University of Washington
Sung Il Park: Texas A&M University

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering 8 individual homecages using a single RF transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies reveals an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite and demonstrates the durability of the miniature wireless device inside harsh gastric conditions.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20421-8

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DOI: 10.1038/s41467-020-20421-8

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