Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Piyushkumar A. Mundra, Nathalie Dhomen, Manuel Rodrigues, Lauge Hjorth Mikkelsen, Nathalie Cassoux, Kelly Brooks, Sara Valpione, Jorge S. Reis-Filho, Steffen Heegaard, Marc-Henri Stern, Sergio Roman-Roman and Richard Marais ()
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Piyushkumar A. Mundra: The University of Manchester
Nathalie Dhomen: The University of Manchester
Manuel Rodrigues: Equipe labellisée par la Ligue Nationale contre le Cancer
Lauge Hjorth Mikkelsen: University of Copenhagen
Nathalie Cassoux: Department of Ocular Oncology
Kelly Brooks: The University of Manchester
Sara Valpione: The University of Manchester
Jorge S. Reis-Filho: Memorial Sloan Kettering Cancer Center
Steffen Heegaard: University of Copenhagen
Marc-Henri Stern: Equipe labellisée par la Ligue Nationale contre le Cancer
Sergio Roman-Roman: Translational Research Department
Richard Marais: The University of Manchester

Nature Communications, 2021, vol. 12, issue 1, 1-7

Abstract: Abstract Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20432-5

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DOI: 10.1038/s41467-020-20432-5

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