Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near-infrared biowindow

Huijing Xiang, Lingzhi Zhao, Luodan Yu, Hongzhong Chen, Chenyang Wei, Yu Chen () and Yanli Zhao ()
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Huijing Xiang: Shanghai University
Lingzhi Zhao: Nanyang Technological University
Luodan Yu: Shanghai University
Hongzhong Chen: Nanyang Technological University
Chenyang Wei: Shanghai Institute of Ceramics, Chinese Academy of Sciences
Yu Chen: Shanghai University
Yanli Zhao: Nanyang Technological University

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Development of organic theranostic agents that are active in the second near-infrared (NIR-II, 1000–1700 nm) biowindow is of vital significance for treating deep-seated tumors. However, studies on organic NIR-II absorbing agents for photo-to-heat energy-converting theranostics are still rare simply because of tedious synthetic routes to construct extended π systems in the NIR-II region. Herein, we design a convenient strategy to engineer highly stable organic NIR-II absorbing theranostic nanoparticles (Nano-BFF) for effective phototheranostic applications via co-assembling first NIR (NIR-I, 650–1000 nm) absorbing boron difluoride formazanate (BFF) dye with a biocompatible polymer, endowing the Nano-BFF with remarkable theranostic performance in the NIR-II region. In vitro and in vivo investigations validate that Nano-BFF can serve as an efficient theranostic agent to achieve photoacoustic imaging guided deep-tissue photonic hyperthermia in the NIR-II biowindow, achieving dramatic inhibition toward orthotopic hepatocellular carcinoma. This work thus provides an insight into the exploration of versatile organic NIR-II absorbing nanoparticles toward future practical applications.

Date: 2021
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DOI: 10.1038/s41467-020-20566-6

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